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Ethylenediaminetetraacetic acid

Also listed as: Chelation therapy; EDTA
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Available Forms
How to Take It
Possible Interactions
Supporting Research


Chelation therapy is a treatment that involves repeated intravenous (IV) administration of a chemical solution of ethylenediaminetetraacetic acid, or EDTA. It is used to treat acute and chronic lead poisoning by pulling toxins (including heavy metals such as lead, cadmium, and mercury) from the bloodstream. The word chelate comes from the Greek root chele, which means "to claw." EDTA has a claw-like molecular structure that binds to heavy metals and other toxins.

EDTA chelation therapy is approved by the U.S. Food and Drug Administration (FDA) as a treatment for lead and heavy metal poisoning. It is also used as an emergency treatment for hypercalcemia (excessive calcium levels) and the control of ventricular arrhythmias (abnormal heart rhythms) associated with digitalis toxicity.

Studies by the National Academy of Sciences/National Research Council in the late 1960s indicated that EDTA was considered possibly effective in the treatment of arteriosclerosis (blocked arteries). However, most well-designed studies have found that it is not effective for heart disease. In fact, many medical organizations including the National Institutes of Health (NIH), the American Medical Association (AMA), the American Heart Association (AHA), and the American College of Cardiology (ACC) have publicly criticized and denounced the practice of EDTA chelation therapy for heart disease.

Proponents of chelation therapy for heart disease claim that EDTA, combined with oral vitamins and minerals, helps dissolve plaques and mineral deposits associated with atherosclerosis (hardening of the arteries). But most reports about using chelation for heart disease have been based on case studies and a few animal studies that may not apply to people. Also, several large-scale clinical trials published in peer-reviewed journals have found that EDTA chelation therapy is no better than placebo in improving symptoms of heart disease. Some medical experts note that the theories about why chelation might help treat atherosclerosis depend on an outdated understanding of how heart disease develops (see Uses section). Finally, and probably most important, the safety of EDTA chelation therapy for people with heart disease is not known.

The NIH National Center for Complementary and Alternative Medicine (NCCAM) is currently funding a study to examine whether EDTA is effective for heart disease. Results are expected in a few years.


Lead poisoning and heavy metal toxicity

Chelation therapy using EDTA is the medically accepted treatment for lead poisoning. EDTA is injected intravenously and once in the bloodstream, it traps lead and other metals, forming a compound that the body can get rid of in the urine. The process generally takes between 1 - 3 hours. Other heavy metal poisonings treated with chelation include mercury, arsenic, aluminum, chromium, cobalt, manganese, nickel, selenium, zinc, tin, and thallium. Chelating agents other than EDTA are also used to clear several of these substances from the bloodstream.

Heavy metal toxicity in humans has been associated with many health conditions, including heart disease, attention deficit/hyperactivity disorder (ADHD), Alzheimer's disease, immune system disorders, gastrointestinal disorders (including irritable bowel syndrome or IBS), and autism.

Digoxin toxicity

EDTA has also been used to treat digoxin toxicity, although most doctors prefer to use other methods. In this case, EDTA helps remove excess levels of digoxin, a medication that is used to treat abnormal rhythms of the heart.


So far, there is no good evidence that EDTA chelation therapy is effective for heart disease. Proponents believe it may help people with atherosclerosis (hardening of the arteries) or peripheral vascular disease (decreased blood flow to the legs) by clearing clogged arteries and improving blood flow. However, a few studies that seem to show it may help have been poorly designed, making the results questionable.

The theory that EDTA clears clogged arteries and improves blood flow is based on an outdated model about what causes heart disease. Other newer theories include the possibility that EDTA functions like an antioxidant, preventing damaging molecules known as free radicals from injuring blood vessel walls and allowing plaque to build up. These ideas are just theories, however.

Most good clinical studies examining EDTA chelation therapy for heart disease and vascular disorders have found that it is no better than placebo. For example, one scientifically rigorous study comparing EDTA chelation therapy to placebo in 84 people with heart disease concluded that those receiving EDTA chelation did no better than those receiving placebo in terms of changes in exercise capacity and quality of life. Several studies evaluating EDTA chelation therapy for peripheral vascular disease did not find any difference between those receiving EDTA and those receiving placebo.

Available Forms

EDTA is a synthetic chemical and not found naturally. Because there is concern that EDTA may deplete important vitamins and minerals, EDTA chelation therapy is often given with essential nutrients (including calcium, B vitamins, vitamin C, and magnesium).

There are advertisements for oral chelating agents available on the market, some of which contain EDTA. However, they have not been studied in clinical trials.

How to Take It


For the treatment of lead poisoning: A doctor may give EDTA intravenously (IV) in a clinic or hospital. The dose depends upon the amount of lead in the child's blood as well as the child's height and weight. Daily treatment for up to 5 days may be required.


For heavy metal toxicity: EDTA chelation therapy is often given intravenously with calcium, magnesium, and vitamins B and C over a period of 1 - 3 hours. The recommended adult dosage varies depending on the size of the person and the amount of lead or other metal in the body. For an average-sized person, the amount may range from 700 - 3,500 mg every 12 hours until the substance is significantly reduced in the bloodstream. The amount used would be determined in a hospital setting.


The most common side effect is a burning sensation at the site of the injection. In addition, some people may have an allergic reaction to EDTA. Other serious side effects that have been reported include low blood sugar, diminished calcium levels, headache, nausea, dangerously low blood pressure, kidney failure, organ damage, irregular heartbeat, seizures, or even death.

According to the Centers for Disease Control and Prevention (CDC), there have been deaths associated with hypocalcemia (low levels of calcium) from intravenous chelation therapy.

A qualified health care provider will monitor blood pressure, blood glucose, cholesterol, organ function, and other vital statistics during treatment with EDTA. EDTA may lower levels of nutrients such as calcium and zinc. Blood tests are performed to monitor vitamin and mineral levels before, during, and after EDTA chelation therapy. Supplements of vitamins and minerals, either orally or intravenously, may be given when needed.

Possible Interactions

Antibiotics, Cephalosporins -- Animal studies suggest that EDTA may increase the absorption of cefmetazole, an antibiotic in a class known as cephalosporins.

Vitamins and minerals -- EDTA chelation therapy may decrease levels of certain vitamins and minerals in the body, including vitamin C, magnesium, iron, and calcium.

Supporting Research

Born, G.R., Geurkink, T.L. Improved peripheral vascular function with low dose intravenous ethylene diamine tetraacetic acid (EDTA). Townsend Letter for Doctors. 1994;132:722-726.

Burns CB, Currie B. The efficacy of chelation therapy and factors influencing mortality in lead intoxicated petrol sniffers. Aust N Z J Med. 1995;25:197–203.

Centers for Disease Control and Prevention (CDC). Deaths associated with hypocalcemia from chelation therapy--Texas, Pennsylvania, and Oregon, 2003-2005. MMWR Morb Mortal Wkly Rep. 2006;55(8):204-7.

Chappell LT. Should EDTA chelation therapy be used instead of long-term clopidogrel plus aspirin to treat patients at risk from drug-eluting stents? Altern Med Rev. 2007 Jun;12(2):152-8. Review.

Chappell LT, Stahl JP. The correlation between EDTA chelation therapy and improvement in cardiovascular function: a meta-analysis. J Adv Med. 1993;6:139–160.

Chappell LT, Wilson J. Chelation therapy for vascular disease [letter]. Circulation. 1999;99:164-166.

Eisenberg D, Davis RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990-1997: Results of a follow-up national survey. JAMA. 1998;280(18):1569-1575.

Ernst E. Chelation therapy for peripheral arterial occlusive disease, a systemic review. Circulation. 1997;96:1031-1033.

Ernst E. Chelation therapy for vascular disease. [Response]. Circulation. 1999;99:166-167.

Evans DAP, Tariq M, Sujata B, McCAnn G, Sobki S. The effects of magnesium sulphate and EDTA in the hypercholesterolaemic rabbit. Diabetes Obesity & Metabolism. 2001;3:417-422.

Guldager B, Jelnes R, Jorgensen SJ, et al. EDTA treatment of intermittent claudication – a double blind, placebo-controlled study. J Intern Med. 1992;231:261-267.

Hancke C, Flytlie K. Benefits of EDTA chelation therapy on arteriosclerosis. J Adv Med. 1993;6:161–172.

Knudston ML, Wyse DG, Galbraith PD, et al. Chelation therapy for ischemic heart disease, a randomized controlled trial. JAMA. 2002;287(4):481-486.

Lamas GA, Ackermann A. Clinical evaluation of chelation therapy: Is there any wheat amidst the chaff? [editorial]. Am Heart J. 2000;140(1):4-5.

Lin JL, Ho HH, Yu CC. Chelation therapy for patients with elevated body lead burden and progressive renal insufficiency. A randomized, controlled trial. Ann Intern Med. 1999;130:7–13.

Lin MC, Nahin R, Gershwin ME, Longhurst JC, Wu KK. State of complementary and alternative medicine in cardiovascular, lung, and blood research: executive summary of a workshop. Circulation. 2001;103(16):2038-2041.

Lyngdorf P, Guldager B, Holm J, Jorgensen SJ, Jeines R. Chelation therapy for intermittent claudication: a double-blind, randomized, controlled trial. Circulation. 1996;93(2):395-396.

Olszewer E, Sabag FC, Carter JP. A pilot double-blind study of sodium-magnesium EDTA in peripheral vascular disease. J Natl Med Assoc. 1990;82:173–177.

Roussel AM, Hininger-Favier I, Waters RS, Osman M, Fernholz K, Anderson RA. EDTA chelation therapy, without added vitamin C, decreases oxidative DNA damage and lipid peroxidation. Altern Med Rev. 2009 Mar;14(1):56-61.

Rudolph CJ, McDonagh EW, Barber RK. A nonsurgical approach to obstructive carotid stenosis using EDTA chelaion. J Adv Med. 1991;4(3):157-167.

Seely DM, Wu P, Mills EJ. EDTA chelation therapy for cardiovascular disease: a systematic review. BMC Cardiovasc Disord. 2005;5:32.

Shrihari JS, Roy A, Prabhakaran D, Reddy KS. Role of EDTA chelation therapy in cardiovascular diseases. Natl Med J India. 2006;19(1):24-6.

Sinha Y, Silove N, Williams K. Chelation therapy and autism. BMJ. 2006;333(7571):756.

Sloth-Nielson J, Guldager B, Mouritzen C, Mouritzen C, Lund EB, Egeblad M, Norregaard O, Jorgensun SJ, Jelnes R. Arteriographic findings in EDTA chelation therapy on peripheral arteriosclerosis. Am J Surg. 1991;162:122–125.

Suzuka T, Furuya A, Kamada A, Nishihata T. Effect of phenothiazines, disodium ethylenediaminetetraacetic acid and diethyl maleate on the in vitrorat colonic transport of cefmetazole and inulin. J Pharmacobio-Dyn. 1987;10:63-71.

Suzuka T, Nishihata T, Yamazaki M, Kamada A. Effect of salicylate and disodium EDTA on the rat intestinal absorption of cefmetazole. Chem PharmBull. 1985;33:4600-4605.

van Rij AM, Solomon C, Packer SGK, Hopkins WG. Chelation therapy for intermittent claudication, a double blind, randomized, controlled trial. Circulation. 1994;90(3):1194-1199.

Review Date: 6/21/2009
Reviewed By: Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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